- CK7 / CK20 profiles (general patterns, specificity varies):
- CK7+ / CK20+:
- Extrahepatic carcinoma of the bile duct (majority) (Pathol Res Pract 2003;199:65)
- Gastric adenocarcinoma, subset (majority are CK7+ / CK20-) (see below)
- Pancreatic adenocarcinoma, minor subset (co-expression associated with worse prognosis, however, majority are CK7+ / CK20-) (see below) (Cancer 2006;106:693)
- Primary mucinous tumors of the ovary (74%) (Am J Surg Pathol 2006;30:1130)
- Pulmonary invasive mucinous adenocarcinoma subset (17%) (Oncol Lett 2018;15:489)
- Sinonasal adenocarcinoma of intestinal type (CK20+ with variable CK7+) (Head Neck Pathol 2016;10:68)
- Small intestinal adenocarcinoma (67%) (Am J Surg Pathol 2004;28:1352)
- Urothelial carcinoma (60%) (Hum Pathol 2002;33:1136)
- CK7+ / CK20-:
- Breast carcinoma (Ann Diagn Pathol 1999;3:350)
- Cervical squamous cell carcinoma and adenocarcinoma (Mod Pathol 2000;13:962)
- Endometrial adenocarcinoma (Int J Gynecol Pathol 2002;21:4)
- Esophageal adenocarcinoma (Am J Surg Pathol 2002;26:1213)
- Gastric adenocarcinoma (71% CK7+, 30% CK20+) (Hum Pathol 2004;35:576)
- Intrahepatic carcinoma of the bile duct (Pathol Res Pract 2003;199:65)
- Lung acinar adenocarcinoma (BMC Cancer 2006;6:31)
- Mesothelioma (pleural and peritoneal) (Cancer. 2001;92:2727, Arch Pathol Lab Med 2018;142:236)
- Ovarian adenocarcinoma, including endometrioid, clear cell, serous, seromucinous (Am J Surg Pathol 2015;39:983, Am J Surg Pathol 2004;28:1499)
- Pancreatic adenocarcinoma (majority but see also above) (Arch Pathol Lab Med 2000;124:1196)
- Renal cell carcinoma, papillary, chromophobe and clear cell papillary types
- Salivary gland carcinoma (93%) (Mod Pathol 2004;17:407)
- Thyroid tumors (adenoma and carcinoma) (Appl Immunohistochem Mol Morphol 2000;8:189)
- Urothelial carcinoma (30%) (Hum Pathol 2002;33:1136)
- CK7- / CK20+:
- Colorectal carcinoma (particularly early stage) (Hum Pathol 2005;36:275)
- Merkel cell carcinoma (88% CK20+ with a perinuclear punctate or dot-like pattern, 23% CK7+) (Appl Immunohistochem Mol Morphol 2000;8:310)
- CK7- / CK20-:
- Adrenal cortical carcinoma and adenoma
- Germ cell tumor, seminoma and embryonal carcinoma subtypes
- Renal cell carcinoma, clear cell type
- Squamous cell carcinoma (with exception of cervix, a subset of head and neck squamous cell carcinomas and a subset of cutaneous squamous cell carcinomas, particularly poorly differentiated tumors, which can express focal-to-partial positivity for CK7) (Head Neck Pathol 2018;12:448, J Cutan Pathol 2010;37:966)
- CK7+ / CK20+:
- Other uses - to distinguish:
- Renal tumors
- Chromophobe renal cell carcinoma (diffuse CK7+) from oncocytoma (rare sprinkled cells express CK7-) (Anal Quant Cytol Histol 2006;28:228)
- Addition of Claudin-7 and CD117 to CK7 or the “three 7 markers” further increases specificity for chromophobe renal cell carcinoma versus other histologic mimics (Dis Markers 2019;2019:4708154)
- Classically, clear cell renal cell carcinoma (CK7-) from other renal cell carcinoma subtypes (including papillary, chromophobe and clear cell papillary); however, CK7 immunoreactivity in clear cell renal cell carcinomas can be variable with low grade clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like groups exhibiting the highest degree of positivity, ranging from 60 - 93% (Histopathology 2019;74:608, Arch Pathol Lab Med 2012;136:410)
- Papillary renal cell carcinoma (CK7+) from metanephric adenoma (CK7-) (Mod Pathol 2006;19:218)
- Adenocarcinoma of distal esophagus from proximal stomach (variable CK7 / CK20 patterns but CK7+ / CK20- pattern favors esophageal origin) (Am J Surg Pathol 2002;26:1213)
- Appendiceal mucinous neoplasms (31% CK7+) from primary ovarian mucinous neoplasms (97% CK7+) (Histopathology 2016;68:977)
- Barrett esophagus from gastric cardiac intestinal metaplasia: Barrett pattern is diffuse CK7+ / surface and crypt epithelium CK20+ but interpretation is affected by fixative and not consistent between laboratories (Hum Pathol 2005;36:58, Mod Pathol 2002;15:611, World J Gastroenterol 2005;11:6360)
- Endometrioid and clear cell carcinoma (CK7+) from yolk sac tumors (CK7- or focal) (Am J Surg Pathol 2004;28:1499)
- Metastatic Krukenberg tumors of the ovary originating from the stomach (93% CK7+) versus colorectum (8% CK7+) (Am J Surg Pathol 2018;42:160)
- Primary lung carcinoma (CK7+ / CK20-) from metastatic colonic carcinoma to lung (CK7- / CK20+) (BMC Cancer 2006;6:31)
- Primary ovarian mucinous tumors can be differentiated from lower gastrointestinal primaries by utilizing a two marker combination of CK7 and SATB2 with greater than 95% accuracy (in many cases primary ovarian mucinous tumors are CK7+, SATB2-) (Modern Pathol 2019;32:1834)
- Renal tumors
Intensify Ck (pro) 1 2 3/4
- CK7 / CK20 profiles (general patterns, specificity varies):
- CK7+ / CK20+:
- Extrahepatic carcinoma of the bile duct (majority) (Pathol Res Pract 2003;199:65)
- Gastric adenocarcinoma, subset (majority are CK7+ / CK20-) (see below)
- Pancreatic adenocarcinoma, minor subset (co-expression associated with worse prognosis, however, majority are CK7+ / CK20-) (see below) (Cancer 2006;106:693)
- Primary mucinous tumors of the ovary (74%) (Am J Surg Pathol 2006;30:1130)
- Pulmonary invasive mucinous adenocarcinoma subset (17%) (Oncol Lett 2018;15:489)
- Sinonasal adenocarcinoma of intestinal type (CK20+ with variable CK7+) (Head Neck Pathol 2016;10:68)
- Small intestinal adenocarcinoma (67%) (Am J Surg Pathol 2004;28:1352)
- Urothelial carcinoma (60%) (Hum Pathol 2002;33:1136)
- CK7+ / CK20-:
- Breast carcinoma (Ann Diagn Pathol 1999;3:350)
- Cervical squamous cell carcinoma and adenocarcinoma (Mod Pathol 2000;13:962)
- Endometrial adenocarcinoma (Int J Gynecol Pathol 2002;21:4)
- Esophageal adenocarcinoma (Am J Surg Pathol 2002;26:1213)
- Gastric adenocarcinoma (71% CK7+, 30% CK20+) (Hum Pathol 2004;35:576)
- Intrahepatic carcinoma of the bile duct (Pathol Res Pract 2003;199:65)
- Lung acinar adenocarcinoma (BMC Cancer 2006;6:31)
- Mesothelioma (pleural and peritoneal) (Cancer. 2001;92:2727, Arch Pathol Lab Med 2018;142:236)
- Ovarian adenocarcinoma, including endometrioid, clear cell, serous, seromucinous (Am J Surg Pathol 2015;39:983, Am J Surg Pathol 2004;28:1499)
- Pancreatic adenocarcinoma (majority but see also above) (Arch Pathol Lab Med 2000;124:1196)
- Renal cell carcinoma, papillary, chromophobe and clear cell papillary types
- Salivary gland carcinoma (93%) (Mod Pathol 2004;17:407)
- Thyroid tumors (adenoma and carcinoma) (Appl Immunohistochem Mol Morphol 2000;8:189)
- Urothelial carcinoma (30%) (Hum Pathol 2002;33:1136)
- CK7- / CK20+:
- Colorectal carcinoma (particularly early stage) (Hum Pathol 2005;36:275)
- Merkel cell carcinoma (88% CK20+ with a perinuclear punctate or dot-like pattern, 23% CK7+) (Appl Immunohistochem Mol Morphol 2000;8:310)
- CK7- / CK20-:
- Adrenal cortical carcinoma and adenoma
- Germ cell tumor, seminoma and embryonal carcinoma subtypes
- Renal cell carcinoma, clear cell type
- Squamous cell carcinoma (with exception of cervix, a subset of head and neck squamous cell carcinomas and a subset of cutaneous squamous cell carcinomas, particularly poorly differentiated tumors, which can express focal-to-partial positivity for CK7) (Head Neck Pathol 2018;12:448, J Cutan Pathol 2010;37:966)
- CK7+ / CK20+:
- Other uses - to distinguish:
- Renal tumors
- Chromophobe renal cell carcinoma (diffuse CK7+) from oncocytoma (rare sprinkled cells express CK7-) (Anal Quant Cytol Histol 2006;28:228)
- Addition of Claudin-7 and CD117 to CK7 or the “three 7 markers” further increases specificity for chromophobe renal cell carcinoma versus other histologic mimics (Dis Markers 2019;2019:4708154)
- Classically, clear cell renal cell carcinoma (CK7-) from other renal cell carcinoma subtypes (including papillary, chromophobe and clear cell papillary); however, CK7 immunoreactivity in clear cell renal cell carcinomas can be variable with low grade clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like groups exhibiting the highest degree of positivity, ranging from 60 - 93% (Histopathology 2019;74:608, Arch Pathol Lab Med 2012;136:410)
- Papillary renal cell carcinoma (CK7+) from metanephric adenoma (CK7-) (Mod Pathol 2006;19:218)
- Adenocarcinoma of distal esophagus from proximal stomach (variable CK7 / CK20 patterns but CK7+ / CK20- pattern favors esophageal origin) (Am J Surg Pathol 2002;26:1213)
- Appendiceal mucinous neoplasms (31% CK7+) from primary ovarian mucinous neoplasms (97% CK7+) (Histopathology 2016;68:977)
- Barrett esophagus from gastric cardiac intestinal metaplasia: Barrett pattern is diffuse CK7+ / surface and crypt epithelium CK20+ but interpretation is affected by fixative and not consistent between laboratories (Hum Pathol 2005;36:58, Mod Pathol 2002;15:611, World J Gastroenterol 2005;11:6360)
- Endometrioid and clear cell carcinoma (CK7+) from yolk sac tumors (CK7- or focal) (Am J Surg Pathol 2004;28:1499)
- Metastatic Krukenberg tumors of the ovary originating from the stomach (93% CK7+) versus colorectum (8% CK7+) (Am J Surg Pathol 2018;42:160)
- Primary lung carcinoma (CK7+ / CK20-) from metastatic colonic carcinoma to lung (CK7- / CK20+) (BMC Cancer 2006;6:31)
- Primary ovarian mucinous tumors can be differentiated from lower gastrointestinal primaries by utilizing a two marker combination of CK7 and SATB2 with greater than 95% accuracy (in many cases primary ovarian mucinous tumors are CK7+, SATB2-) (Modern Pathol 2019;32:1834)
- Renal tumors
- Also in 2011, Bettinardi Golf recognized 2nd Swing as a premier putter fitter and awarded us the Studio B Fitting Studio. 2nd Swing Minnetonka is 1 of only 3 Studio B Fitting Studios in the country. In 2013, 2nd Swing achieved a long sought after goal of becoming a Ping Authorized Internet Retailer (A.I.R.). 2nd Swing is 1 of only 10 A.I.R.
- Ask any question and get an answer from our subject experts in as little as 2 hours.
![(pro) (pro)](https://sanet.pics/storage-1/1115/or12rPGzguTLYrfTFeOKVlBBGe7S6DWu.jpg)
Intensify Ck (pro) 1 2 360
Ink2go 1 8 0 m. Amadeus pro 2 3 1 download free. Start studying MSU Financial Management Quizzes 1,2,3,4. Learn vocabulary, terms, and more with flashcards, games, and other study tools.